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Research Departments > Department of Translational Neuroscience > Neurovascular Research Group > Publications

Research Report Personnel Publications Other


  • Gomez-Gonzalo M, Martin-Fernandez M, Mederos S, Hernandez-Vivanco A, Jamison S, Fernandez AP, Serrano J, Calero P, Futch HS, Corpas R, Sanfeliu C, Martinez-Murillo R, Perea G, Araque A: Neuron-astrocyte signalling is preserved in the ageing brain. Glia. En prensa, 2017.

  • Serrano MP, Herrero-Labrador R, Futch HS, Serrano J, Romero A, Fernandez AP, Samadi A, Unzeta M, Marco-Contelles J, Martinez-Murillo R: The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease. J Psychiatry Neurosci 20-9-2017;42:59-69.

  • Ochoa-Callejero L, Pozo-Rodrigalvarez A, Martinez-Murillo R, Martinez A: Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage. Sci Rep 2016;6:33495.

  • Marco-Contelles J, Unzeta M, Bolea I, Esteban G, Ramsay RR, Romero A, Martinez-Murillo R, Carreiras MC, Ismaili L: ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy. Front Neurosci 2016;10:294.

  • Rey-Funes M, Larrayoz IM, Fernandez JC, Contartese DS, Rolon F, Inserra PI, Martinez-Murillo R, Lopez-Costa JJ, Dorfman VB, Martinez A, Loidl CF: Methylene blue prevents retinal damage in an experimental model of ischemic proliferative retinopathy. Am J Physiol Regul Integr Comp Physiol 2016;310:R1011-R1019.

  • Fernandez AP, Serrano J, Guedan MA, Futch HS, Martinez-Murillo R: Adrenomedullin Expression in Alzheimer's Brain. Curr Alzheimer Res 2016;13:428-438.

  • Defterali C, Verdejo R, Peponi L, Martin ED, Martinez-Murillo R, Lopez-Manchado MA, Vicario-Abejon C: Thermally reduced graphene is a permissive material for neurons and astrocytes and de novo neurogenesis in the adult olfactory bulb in vivo. Biomaterials 2016;82:84-93.

  • Barios JA, Pisarchyk L, Fernandez-Garcia L, Barrio LC, Ramos M, Martinez-Murillo R, Gonzalez-Nieto D: Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion. J Cereb Blood Flow Metab 2016;36:606-620.

  • Rodriguez-Munoz M, Sanchez-Blazquez P, Herrero-Labrador R, Martinez-Murillo R, Merlos M, Vela JM, Garzon J: The sigma1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control. Antioxid Redox Signal 1-4-2015;22:799-818.

  • Genis L, Davila D, Fernandez S, Pozo-Rodrigalvarez A, Martinez-Murillo R, Torres-Aleman I: Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury. F1000Res 2014;3:28.

  • Ares-Santos S, Granado N, Espadas I, Martinez-Murillo R, Moratalla R: Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining. Neuropsychopharmacology 2014;39:1066-1080.

  • Sanchez-Mendoza E, Bellver-Landete V, Merino JJ, Gonzalez MP, Martinez-Murillo R, Oset-Gasque MJ: Review: Could neurotransmitters influence neurogenesis and neurorepair after stroke? Neuropathol Appl Neurobiol 2013;39:722-735.

  • Rey-Funes M, Dorfman VB, Ibarra ME, Pena E, Contartese DS, Goldstein J, Acosta JM, Larrayoz IM, Martinez-Murillo R, Martinez A, Loidl CF: Hypothermia prevents gliosis and angiogenesis development in an experimental model of ischemic proliferative retinopathy. Invest Ophthalmol Vis Sci 23-4-2013;54:2836-2846.

  • Sanchez-Mendoza E, Bellver-Landete V, Gonzalez MP, Merino JJ, Martinez-Murillo R, Oset-Gasque MJ: [Brain repair after ischemic stroke: role of neurotransmitters in post-ischemic neurogenesis]. Rev Neurol 1-11-2012;55:533-542.

  • Muneton-Gomez VC, Doncel-Perez E, Fernandez AP, Serrano J, Pozo-Rodrigalvarez A, Vellosillo-Huerta L, Taylor JS, Cardona-Gomez GP, Nieto-Sampedro M, Martinez-Murillo R: Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations. Front Cell Neurosci 2012;6:30.

  • Pozo-Rodrigalvarez A, Gradillas A, Serrano J, Fernandez AP, Martinez-Murillo R, Perez-Castells J: New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714. Eur J Med Chem 2012;54:439-446.

  • Garzon J, Rodriguez-Munoz M, Vicente-Sanchez A, Garcia-Lopez MA, Martinez-Murillo R, Fischer T, Sanchez-Blazquez P: SUMO-SIM interactions regulate the activity of RGSZ2 proteins. PLoS One 2011;6:e28557.

  • Fernandez AP, Serrano J, Amorim MA, Pozo-Rodrigalvarez A, Martinez-Murillo R: Adrenomedullin and nitric oxide: implications for the etiology and treatment of primary brain tumors. CNS Neurol Disord Drug Targets 2011;10:820-833.

  • Garzon J, Rodriguez-Munoz M, Vicente-Sanchez A, Bailon C, Martinez-Murillo R, Sanchez-Blazquez P: RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway. Antioxid Redox Signal 15-8-2011;15:873-887.

  • Rey-Funes M, Ibarra ME, Dorfman VB, Serrano J, Fernandez AP, Martinez-Murillo R, Martinez A, Coirini H, Rodrigo J, Loidl CF: Hypothermia prevents nitric oxide system changes in retina induced by severe perinatal asphyxia. J Neurosci Res 2011;89:729-743.

  • Garcia-Bonilla L, Rosell A, Torregrosa G, Salom JB, Alborch E, Gutierrez M, ez-Tejedor E, Martinez-Murillo R, Agulla J, Ramos-Cabrer P, Castillo J, Gasull T, Montaner J: Recommendations guide for experimental animal models in stroke research. Neurologia 2011;26:105-110.

  • Garcia-Lopez P, Garcia-Marin V, Martinez-Murillo R, Freire M: Cajal's achievements in the field of the development of dendritic arbors. Int J Dev Biol 2010;54:1405-1417.

  • Fernandez AP, Serrano J, Martinez-Murillo R, Martinez A: Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity. Endocrinology 2010;151:4908-4915.

  • Hurtado O, Serrano J, Sobrado M, Fernandez AP, Lizasoain I, Martinez-Murillo R, Moro MA, Martinez A: Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. Neuroscience 15-12-2010;171:885-892.

  • Fernandez AP, Pozo-Rodrigalvarez A, Serrano J, Martinez-Murillo R: Nitric oxide: target for therapeutic strategies in Alzheimer's disease. Curr Pharm Des 2010;16:2837-2850.

  • Serrano J, Fernandez AP, Martinez-Murillo R, Martinez A: High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease. Oncogene 15-4-2010;29:2165-2171.

  • E. Vergaño-Vera, A.P. Fernández, A. Hurtado-Chong, C. Vicario- Abejón and A. Martínez. Lack of adrenomedullin affects growth and differentation of adult neural stem/progenitor cells. Cell and Tissue Research 340:1-11 (2010).

  • Garcia-Lopez P, Garcia-Marin V, Martinez-Murillo R, Freire M: Updating old ideas and recent advances regarding the Interstitial Cells of Cajal. Brain Res Rev 2009;61:154-169.

  • Martinez-Murillo R, Serrano J, Fernandez AP, Martinez A: Whole-body periodic acceleration reduces brain damage in a focal ischemia model. Neuroscience 18-2-2009;158:1390-1396.

  • A.P. Fernández, Julia Serrano, Lino Tessarollo, Frank Cuttitta and Alfredo Martínez. Lack of adrenomedullin in the mouse brain results in behavioural changes, anxiety, and lower survival under stress conditions. PNAS vol. 105, nº 34 (2008) 12581-12586

  • Julia Serrano, A.P. Fernández, Jaime Sánchez, José Rodrigo and Alfredo Martínez. Adrenomedullina Expression is Up-Regulated by Acute Hypobaric Hypoxia in the Cerebral Cortex of the Adult Rat. Brain Pathology, 18 (2008) 434-442

  • Martinez-Murillo R, Martinez A: Standardization of an orthotopic mouse brain tumor model following transplantation of CT-2A astrocytoma cells. Histol Histopathol 2007;22:1309-1326.

  • Fernández AP, Serrano J, Rodrigo J, Monleón E, Monzón M, Vargas A, Babiola JJ, Martínez-Murillo R, Martínez A: Changes in the expression pattern of the nitrergic system of ovine cerebellum affected by scrapie. J Neuropathol. Exp. Neurol. 2007; 66(3): 196-207.

  • Martinez-Murillo R, Fernandez AP, Serrano J, Rodrigo J, Salas E, Mourelle M, Martinez A: The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model. Neurosci Lett 26-3-2007;415:149-153.

  • Serrano J, Fernandez AP, Martinez-Murillo R, Alonso D, Rodrigo J, Salas E, Mourelle M, Martinez A: The nitric oxide donor LA 419 decreases ischemic brain damage. Int J Mol Med 2007;19:229-236.

  • Navarro-Antolín J., Redondo-Horcajo M., Zaragoza C, Alvarez-Barrientos A., A.P. Fernández, León-Gómez E., J. Rodrigo and Lamas S. Role of peroxynitrite in endothelial damage mediated by Ciclosporine A. Free Radical Biology and Medicine 43: 394-403 (2007).

  • S. LLorens, A.P. Fernández, and E.Nava. Cardiovascular and renal alterations on the nitric oxide pathway in spontaneous hypertension and ageing. Clinical Hemorheology and microcirculation 37: 149-156(2007).

  • J. Serrano, J. M. Encinas, A.P. Fernández, J. Rodrigo and A. Martínez. Effects of acute hypobaric hypoxia on the nitric oxide system of the rat cerebral cortex: protective role of nitric oxide inhibitors. Neuroscience 142, 799-808 (2006).

  • Rodrigo J, Fernandez AP, Serrano J, Monzon M, Monleon E, Badiola JJ, Climent S, Martinez-Murillo R, Martinez A: Distribution and expression pattern of the nitrergic system in the cerebellum of the sheep. Neuroscience 2006;139:889-898.

  • Martinez A, Marin VG, Junquera SR, Martinez-Murillo R, Freire M: The contributions of Santiago Ramon y Cajal to cancer research - 100 years on. Nat Rev Cancer 2005;5:904-909.

  • Rodrigo J., Fernández A.P., Serrano J., Peinado M.A.., Martínez A. The role of the free radicals in cerebral hypoxia. Free Radic. Biol. Med. 39 (1): 26-50 (2005).

  • Lopez-Rivera E, Lizarbe TR, Martinez-Moreno M, Lopez-Novoa JM, Rodriguez-Barbero A, Rodrigo J, Fernandez AP, Alvarez-Barrientos A, Lamas S, Zaragoza C. Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration. Proc Natl Acad Sci U S A 102: 3685-3690 (2005).

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